Polynucleotides and Profhilo are frequently confused. Both regenerative, both injectable, both focused on skin quality. Here's a clear clinical account of what distinguishes them and how to choose between them.

Polynucleotides are among the better-tolerated injectable treatments in aesthetic medicine. Here we set out the side effects, address the DNA-derived origin question, and explain why practitioner experience remains the key safety variable.

The evidence on polynucleotide longevity is still developing, but clinical experience suggests results persist for six to nine months after a completed course. Here's an account of what we're seeing, and when maintenance treatment tends to be appropriate.

Polynucleotides work best for patients concerned by loss of superficial skin quality rather than volume or structure. Here we set out who tends to respond best, and who we'd steer toward something different.

Crepey under-eye skin is one of the hardest problems to treat, because so few treatments are appropriate there. Here's why polynucleotides are increasingly our preferred option for this delicate area.

Polynucleotides are one of the fastest-growing topics in aesthetics, but many patients are unsure what they actually do. This guide explains how they work, who they may suit, and what kind of results can realistically be expected.

I started using polynucleotides with my scepticism intact. Almost hoping to confirm what I suspected; that this was another treatment whose promise would not survive contact with real patients. The early results gave me pause. They were better than I expected. But I am not yet ready to set my scepticism down entirely and I think the reasons why are worth examining carefully.